Influence of donor brain death duration on outcomes following heart transplantation: A United Network for Organ Sharing Registry analysis.

ABSTRACT:

Objectives

We hypothesized that an increased duration of donor brain death may worsen survival following orthotopic heart transplantation.

Methods

The United Network for Organ Sharing Registry was queried for first-time, adult recipients of heart transplant from 2006 to 2018. Cox proportional hazards with penalized smooth splines was used to stratify patients based on donor brain death interval: shorter (<22 hours), reference (22-42 hours), and longer (>42 hours). Overall survival was estimated using Kaplan-Meier and Cox proportional hazards models.

Results

A total of 22,960 patients met study criteria (9.2% shorter, 55.0% reference, and 35.8% longer). Longer brain death duration recipients were more likely to have a later year of transplant and have a mechanical brid

SUBMITTER: Jawitz OK 

PROVIDER: S-EPMC6821595 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature