Fornix Stimulation Induces Metabolic Activity and Dopaminergic Response in the Nucleus Accumbens.

ABSTRACT: The Papez circuit, including the fornix white matter bundle, is a well-known neural network that is involved in multiple limbic functions such as memory and emotional expression. We previously reported a large-animal study of deep brain stimulation (DBS) in the fornix that found stimulation-induced hemodynamic responses in both the medial limbic and corticolimbic circuits on functional resonance imaging (fMRI) and evoked dopamine responses in the nucleus accumbens (NAc), as measured by fast-scan cyclic voltammetry (FSCV). The effects of DBS on the fornix are challenging to analyze, given its structural complexity and connection to multiple neuronal networks. In this study, we extend our earlier work to a rodent model wherein we characterize regional brain activity changes resulting from fo

SUBMITTER: Shin H 

PROVIDER: S-EPMC6821687 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature