MicroRNA-146a-deficient mice develop immune complex glomerulonephritis.

ABSTRACT: MicroRNAs (miRNAs) play an important role in the kidneys under physiological and pathological conditions, but their role in immune glomerulonephritis is unclear. miR-146a has been identified as a key player in innate immunity and inflammatory responses, and in the kidney, this miRNA is involved in the response of injured tubular cells. We studied the renal and immune phenotypes of miR-146a^+/+ and miR-146a^-/- mice at 12 months of age, and the results showed that miR-146a^-/- mice developed autoimmunity during aging, as demonstrated by circulating antibodies targeting double-stranded DNA and an immune complex-mediated glomerulonephritis associated with a mild renal immune infiltrate. In addition, miR-146a^-/- mice showed reduced expression of the tra

SUBMITTER: Amrouche L 

PROVIDER: S-EPMC6821765 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature