Molecular Imaging of Endometriosis Tissues using Desorption Electrospray Ionization Mass Spectrometry.

ABSTRACT: Endometriosis is a pathologic condition affecting approximately 10% of women in their reproductive years. Characterized by abnormal growth of uterine endometrial tissue in other body areas, endometriosis can cause severe abdominal pain and/or infertility. Despite devastating consequences to patients' quality of life, the causes of endometriosis are not fully understood and validated diagnostic markers for endometriosis have not been identified. Molecular analyses of ectopic and eutopic endometrial tissues could lead to enhanced understanding of the disease. Here, we apply desorption electrospray ionization (DESI) mass spectrometry (MS) imaging to chemically and spatially characterize the molecular profiles of 231 eutopic and ectopic endometrial tissues from 89 endometriosis patients. DESI-

SUBMITTER: Feider CL 

PROVIDER: S-EPMC6821845 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature