G ST ' , Jost's D, and F_ST are similarly constrained by allele frequencies: A mathematical, simulation, and empirical study.

ABSTRACT: Statistics G ST ' and Jost's D have been proposed for replacing F_ST as measures of genetic differentiation. A principal argument in favour of these statistics is the independence of their maximal values with respect to the subpopulation heterozygosity H_S , a property not shared by F_ST . Nevertheless, it has been unclear if these alternative differentiation measures are constrained by other aspects of the allele frequencies. Here, for biallelic markers, we study the mathematical properties of the maximal values of G ST ' and D, comparing them to those of F_ST . We show that G ST ' and D exhibit the same peculiar frequency-dependence phenomena as F_ST , including a maximal value as a function of the frequency of the most frequent allele

SUBMITTER: Alcala N 

PROVIDER: S-EPMC6821915 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature