Transgenic mouse models expressing human and macaque prion protein exhibit similar prion susceptibility on a strain-dependent manner.

ABSTRACT: Cynomolgus macaque has been used for the evaluation of the zoonotic potential of prion diseases, especially for classical-Bovine Spongiform Encephalopathy (classical-BSE) infectious agent. PrP amino acid sequence is considered to play a key role in the susceptibility to prion strains and only one amino acid change may alter this susceptibility. Macaque and human-PrP sequences have only nine amino acid differences, but the effect of these amino acid changes in the susceptibility to dissimilar prion strains is unknown. In this work, the transmissibility of a panel of different prions from several species was compared in transgenic mice expressing either macaque-PrP^C (TgMac) or human-PrP^C (Hu-Tg340). Similarities in the transmissibility of most prion strains were observe

SUBMITTER: Espinosa JC 

PROVIDER: S-EPMC6821920 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature