Tbx15 is required for adipocyte browning induced by adrenergic signaling pathway.

ABSTRACT:

Objective

The T-box gene Tbx15 is abundantly expressed in adipose tissues, especially subcutaneous and brown fat. Although its expression is correlated with obesity, its precise biological role in adipose tissue is poorly understood in vivo. Here we investigated the function of Tbx15 in brown adipose thermogenesis and white adipose browning in vivo.

Methods

In the present study, we generated adipose-specific Tbx15 knockout (AKO) mice by crossing Tbx15 floxed mice with adiponectin-Cre mice to delineate Tbx15 function in adipose tissues. We systematically investigated the influence of Tbx15 on brown adipose thermogenesis and white adipose browning in mice, as well as the possible underlying molecular mechanism.

Results

Upon cold exposure, adipocyte browning in inguinal

SUBMITTER: Sun W 

PROVIDER: S-EPMC6822144 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature