CAMP-MicroRNA-203-IFNγ network regulates subcutaneous white fat browning and glucose tolerance.

ABSTRACT:

Objective

Brown and beige adipocytes in humans and rodents are specialized to burn lipids for heat generation as a natural defense against cold and obesity, which is advantageous to metabolic homeostasis. MicroRNAs as another regulatory layer to regulate metabolic homeostasis attracted a lot of attentions. Our previous work revealed microRNA (miR)-203 as a brown adipocyte-enriched microRNA involved in brown adipocytes development. However, the potential role of miR-203 in adipose tissue metabolic homeostasis has not been determined in vivo. In this study, we investigate the potential role of miR-203 in subcutaneous white adipose tissue (sub-WAT) browning and metabolic homeostasis.

Methods

We investigated the relationship between miR-203 and energy homeostasis in adipose tiss

SUBMITTER: Guo X 

PROVIDER: S-EPMC6822238 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature