Long noncoding RNA ZNF667-AS1 reduces tumor invasion and metastasis in cervical cancer by counteracting microRNA-93-3p-dependent PEG3 downregulation.

ABSTRACT: Zinc finger protein 667-antisense RNA 1 (ZNF667-AS1), located on human chromosome 19q13.43, is a member of the C2H2 zinc finger protein family. Herein, we aimed to analyze the interactions between ZNF667-AS1, microRNA-93-3p (miR-93-3p), and paternally expressed gene 3 (PEG3) and to explore their roles in the tumorigenesis of cervical cancer (CC). Differentially expressed long noncoding RNAs and miRNAs related to CC were determined using gene expression datasets sourced from the Gene Expression Omnibus database. Subsequently, the regulatory relationships between ZNF667-AS1 and miR-93-3p and between miR-93-3p and PEG3 were identified using the dual-luciferase reporter gene assay. In addition, the expression of miR-93-3p and ZNF667-AS1 was up- or downregulated in CC cells (HeLa), in order to

SUBMITTER: Li YJ 

PROVIDER: S-EPMC6822248 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature