Physiological roles of the GIP receptor in murine brown adipose tissue.

ABSTRACT:

Objective

Glucose-dependent insulinotropic polypeptide (GIP) is secreted from the gut in response to nutrient ingestion and promotes meal-dependent insulin secretion and lipid metabolism. Loss or attenuation of GIP receptor (GIPR) action leads to resistance to diet-induced obesity through incompletely understood mechanisms. The GIPR is expressed in white adipose tissue; however, its putative role in brown adipose tissue (BAT) has not been explored.

Methods

We investigated the role of the GIPR in BAT cells in vitro and in BAT-specific (Gipr^BAT-/-) knockout mice with selective elimination of the Gipr within the Myf5⁺ expression domain. We analyzed body weight, adiposity, glucose homeostasis, insulin and lipid tolerance, energy expenditure, food intake, bo

SUBMITTER: Beaudry JL 

PROVIDER: S-EPMC6822254 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature