Enzyme-Catalyzed Kinetic Resolution of Chiral Precursors to Antiviral Prodrugs.

ABSTRACT: Nucleoside analogues are among the most common medications given for the treatment of viral infections and cancers. The therapeutic effectiveness of nucleoside analogues can be dramatically improved by phosphorylation. The ProTide approach was developed using a phosphorylated nucleoside that is masked by esterification with an amino acid and phenol forming a chiral phosphorus center. The biological activity of the ProTides depends, in part, on the stereochemistry at phosphorus, and thus, it is imperative that efficient methods be developed for the chemical synthesis and isolation of diastereomerically pure ProTides. Chiral ProTides are often synthesized by direct displacement of a labile phenol (p-nitrophenol or pentafluorophenol) from a chiral phosphoramidate precursor with the app

SUBMITTER: Xiang DF 

PROVIDER: S-EPMC6822272 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature