Adaptive mechanical ventilation with automated minimization of mechanical power-a pilot randomized cross-over study.

ABSTRACT: BACKGROUND:Adaptive mechanical ventilation automatically adjusts respiratory rate (RR) and tidal volume (VT) to deliver the clinically desired minute ventilation, selecting RR and VT based on Otis' equation on least work of breathing. However, the resulting VT may be relatively high, especially in patients with more compliant lungs. Therefore, a new mode of adaptive ventilation (adaptive ventilation mode 2, AVM2) was developed which automatically minimizes inspiratory power with the aim of ensuring lung-protective combinations of VT and RR. The aim of this study was to investigate whether AVM2 reduces VT, mechanical power, and driving pressure (ΔPstat) and provides similar gas exchange when compared to adaptive mechanical ventilation based on Otis' equation. METHODS:A prospective randomize

SUBMITTER: Becher T 

PROVIDER: S-EPMC6822420 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature