Identification of novel non-synonymous variants associated with type 2 diabetes-related metabolites in Korean population.

ABSTRACT: Metabolome-genome wide association studies (mGWASs) are useful for understanding the genetic regulation of metabolites in complex diseases, including type 2 diabetes (T2D). Numerous genetic variants associated with T2D-related metabolites have been identified in previous mGWASs; however, these analyses seem to have difficulty in detecting the genetic variants with functional effects. An exome array focussed on potentially functional variants is an alternative platform to obtain insight into the genetics of biochemical conversion processes. In the present study, we performed an mGWAS using 27,140 non-synonymous variants included in the Illumina HumanExome BeadChip and nine T2D-related metabolites identified by a targetted metabolomics approach to evaluate 2,338 Korean individuals from the K

SUBMITTER: Park TJ 

PROVIDER: S-EPMC6822494 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature