Homology modeling and molecular dynamics dimulation study of β carbonic anhydrase of Ascaris lumbricoides.

ABSTRACT: Ascaris lumbricoides is the prevalent parasite causing ascariasis by infecting the human alimentary tract. This is common in the jejunum of small intestine. Therefore, it is of interest to describe the target protein β Carbonic Anhydrase involved in Ascariasis. Carbonic anhydrase (CAs, the metallo enzymes) is encoded by six evolutionary divergent gene families α, β,γ, δ, ζ, and η, which contain zinc ion in their catalytic active site. β-CA is found in plants, algae, fungi, bacteria, protozoans, arthropods, and nematodes and completely absent in vertebrate genomes. The absence of β-CA protein in vertebrate makes the enzyme an important target for inhibitory studies against helminthic infection. The sequence to function related information and 3D structure data for β-CA of Ascaris lumbricoid

SUBMITTER: Yadav M 

PROVIDER: S-EPMC6822520 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature