Mechanics and pharmacology of substrate selection and transport by eukaryotic ABC exporters.

ABSTRACT: Much structural information has been amassed on ATP-binding cassette (ABC) transporters, including hundreds of structures of isolated domains and an increasing array of full-length transporters. The structures capture different steps in the transport cycle and have aided in the design and interpretation of computational simulations and biophysics experiments. These data provide a maturing, although still incomplete, elucidation of the protein dynamics and mechanisms of substrate selection and transit through the transporters. We present an updated view of the classical alternating-access mechanism as it applies to eukaryotic ABC transporters, focusing on type I exporters. Our model helps frame the progress in, and remaining questions about, transporter energetics, how substrates are select

SUBMITTER: Srikant S 

PROVIDER: S-EPMC6822692 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature