Bone Marrow and Tumor Radiomics at ¹⁸F-FDG PET/CT: Impact on Outcome Prediction in Non-Small Cell Lung Cancer.

ABSTRACT: Background Primary tumor maximum standardized uptake value is a prognostic marker for non-small cell lung cancer. In the setting of malignancy, bone marrow activity from fluorine 18-fluorodeoxyglucose (FDG) PET may be informative for clinical risk stratification. Purpose To determine whether integrating FDG PET radiomic features of the primary tumor, tumor penumbra, and bone marrow identifies lung cancer disease-free survival more accurately than clinical features alone. Materials and Methods Patients were retrospectively analyzed from two distinct cohorts collected between 2008 and 2016. Each tumor, its surrounding penumbra, and bone marrow from the L3-L5 vertebral bodies was contoured on pretreatment FDG PET/CT images. There were 156 bone marrow and 512 tumor and penumbra radiomic featur

SUBMITTER: Mattonen SA 

PROVIDER: S-EPMC6822770 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature