Neoadjuvant cryotherapy improves dysphagia and may impact remission rates in advanced esophageal cancer.

ABSTRACT: Background and study aims  Liquid nitrogen spray cryotherapy (LNSC) can provide rapid dysphagia relief, and is postulated to stimulate a local antitumor immune response. The aim of this prospective pilot clinical trial was to evaluate the safety and efficacy of LNSC when administered prior to chemoradiotherapy. Patients and methods  Treatment-naïve adult patients with dysphagia at the time of biopsy-proven squamous carcinoma or adenocarcinoma of the esophagus were prospectively enrolled at two tertiary medical centers. Patients underwent a single session of LNSC. The primary outcome measure was change in dysphagia at 1 and 2 weeks post-cryotherapy. A secondary outcome measure was clinical complete response rate (CR) following chemoradiotherapy. Results  Twenty-five patients were screened,

SUBMITTER: Shah T 

PROVIDER: S-EPMC6823095 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature