The Relationship Between Local Field Potentials and the Blood-Oxygenation-Level Dependent MRI Signal Can Be Non-linear.

ABSTRACT: Functional magnetic resonance imaging (fMRI) is currently one of the most important neuroimaging methods in neuroscience. The image contrast in fMRI relies on the blood-oxygenation-level dependent (BOLD) signal, which indirectly reflects neural activity through neurovascular coupling. Because the mechanism that links the BOLD signal to neural activities involves multiple complicated processes, where neural activity, regional metabolism, hemodynamics, and the BOLD signal are all inter-connected, understanding the quantitative relationship between the BOLD signal and the underlying neural activities is crucial for interpreting fMRI data. Simultaneous local field potential (LFP) and fMRI recordings provide a method to study neurovascular coupling. There were a few studies that have shown non-

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6823197 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature