Biochemical characterization of Plasmodium falciparum parasite specific helicase 1 (PfPSH1).

ABSTRACT: Malaria, a disease caused by infection with parasites of the genus Plasmodium, causes millions of deaths worldwide annually. Of the five Plasmodium species that can infect humans, Plasmodium falciparum causes the most serious parasitic infection. The emergence of drug resistance and the ineffectiveness of old therapeutic regimes against malaria mean there is an urgent need to better understand the basic biology of the malaria parasite. Previously, we have reported the presence of parasite-specific helicases identified through genome-wide analysis of the P. falciparum (3D7) strain. Helicases are involved in various biological pathways in addition to nucleic acid metabolism, making them an important target of study. Here, we report the detailed biochemical characterization of P. falciparum p

SUBMITTER: Chauhan M 

PROVIDER: S-EPMC6823286 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature