Therapies to limit myocardial injury in animal models of myocarditis: a systematic review and meta-analysis.

ABSTRACT: Current myocarditis guidelines do not advocate treatment to prevent myocardial injury and scar deposition in patients with myocarditis and normal left ventricular ejection fraction. We aimed to ascertain the utility of beta blockers, calcium channel blockers and antagonists of the renin-angiotensin system in ameliorating myocardial injury, scar formation and calcification in animal in vivo models of myocarditis. The project was prospectively registered with the PROSPERO database of systematic reviews (CRD42018089336). Primary outcomes (necrosis, fibrosis and calcification) were meta-analysed with random-effects modelling. 52 studies were systematically reviewed. Meta-analysis was performed compared with untreated controls. In each study, we identified all independent comparisons of treatme

SUBMITTER: Silverblatt JA 

PROVIDER: S-EPMC6823299 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature