Association of BMP15 and GDF9 variants to premature ovarian insufficiency.

ABSTRACT:

Purpose

To identify genetic variation associated to premature ovarian insufficiency (POI).

Methods

A total of 74 women with POI (group POI), 45 women with increased FSH levels (group high FSH), and 88 controls (non-POI) were studied. Genotyping of BMP15:c.-9C>G (rs3810682), BMP15:c.328+905A>G (rs3897937), and BMP15:c.852C>T (rs17003221); and GDF9:c.134-694G>A (rs4705974), GDF9:c.-31-951G>A (rs11748063), GDF9:c.-152G>C (rs30177), and GDF9:g.1073C>T (rs803224) was performed by the TaqMan methodology. Chi-square and Fisher's exact tests were performed to evaluate the distribution of genotypes, alleles, odds ratio, and the Hardy-Weinberg equilibrium of each variation. Haplotype analysis was performed for each gene considering the case and control groups. Bonferroni's correction

SUBMITTER: Santos M 

PROVIDER: S-EPMC6823326 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature