The Signaling Pathways Project, an integrated 'omics knowledgebase for mammalian cellular signaling pathways.

ABSTRACT: Mining of integrated public transcriptomic and ChIP-Seq (cistromic) datasets can illuminate functions of mammalian cellular signaling pathways not yet explored in the research literature. Here, we designed a web knowledgebase, the Signaling Pathways Project (SPP), which incorporates community classifications of signaling pathway nodes (receptors, enzymes, transcription factors and co-nodes) and their cognate bioactive small molecules. We then mapped over 10,000 public transcriptomic or cistromic experiments to their pathway node or biosample of study. To enable prediction of pathway node-gene target transcriptional regulatory relationships through SPP, we generated consensus 'omics signatures, or consensomes, which ranked genes based on measures of their significant differential expression

SUBMITTER: Ochsner SA 

PROVIDER: S-EPMC6823428 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature