Asian and African lineage Zika viruses show differential replication and innate immune responses in human dendritic cells and macrophages.

ABSTRACT: Zika virus (ZIKV) infections in humans are considered to be mild or subclinical. However, during the recent epidemics in the Pacific Islands and the Americas, the infection was associated with Quillain-Barré syndrome and congenital infections with fetal brain abnormalities, including microcephaly. Thus, more detailed understanding of ZIKV-host cell interactions and regulation of innate immune responses by strains of differential evolutionary origin is required. Here, we characterized the infection and immune responses triggered by two epidemic Asian/American lineage viruses, including an isolate from fetal brains, and a historical, low passage 1947 African lineage virus in human monocyte-derived dendritic cells (DCs) and macrophages. The epidemic Asian/American ZIKV replicated well and ind

SUBMITTER: Osterlund P 

PROVIDER: S-EPMC6823455 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature