Protein interaction disruption in cancer.

ABSTRACT:

Background

Most methods that integrate network and mutation data to study cancer focus on the effects of genes/proteins, quantifying the effect of mutations or differential expression of a gene and its neighbors, or identifying groups of genes that are significantly up- or down-regulated. However, several mutations are known to disrupt specific protein-protein interactions, and network dynamics are often ignored by such methods. Here we introduce a method that allows for predicting the disruption of specific interactions in cancer patients using somatic mutation data and protein interaction networks.

Methods

We extend standard network smoothing techniques to assign scores to the edges in a protein interaction network in addition to nodes. We use somatic mutations as input to

SUBMITTER: Ruffalo M 

PROVIDER: S-EPMC6823625 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature