Ginsenoside Rg1 supplementation clears senescence-associated β-galactosidase in exercising human skeletal muscle.

ABSTRACT:

Background

Ginsenoside Rg1 has been shown to clear senescence-associated beta-galactosidase (SA-β-gal) in cultured cells. It remains unknown whether Rg1 can influence SA-β-gal in exercising human skeletal muscle.

Methods

To examine SA-β-gal change, 12 young men (age 21 ± 0.2 years) were enrolled in a randomized double-blind placebo controlled crossover study, under two occasions: placebo (PLA) and Rg1 (5 mg) supplementations 1 h prior to a high-intensity cycling (70% VO_2max). Muscle samples were collected by multiple biopsies before and after cycling exercise (0 h and 3 h). To avoid potential effect of muscle biopsy on performance assessment, cycling time to exhaustion test (80% VO_2max) was conducted on another 12 participants (age 23 ± 0.5 years) with

SUBMITTER: Wu J 

PROVIDER: S-EPMC6823780 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature