Immunoglobulin A N-glycosylation Presents Important Body Fluid-specific Variations in Lactating Mothers.

ABSTRACT: Secretory Immunoglobulin A (SIgA) is central to mucosal immunity: represents one of the main immunological mechanisms of defense against the potential attack of pathogens. During lactation SIgA is produced by plasmablasts in the mammary gland and is present in breast milk, playing a vital role in the passive immunity of the newborn. Interestingly, the different components of SIgA are highly N-glycosylated, and these N-Glycans have an essential role in health maintenance. In this work, we performed a glycomic study to compare N-glycosylation of SIgA purified from mature breast milk and saliva, and plasma IgA from the same lactating participants. Our results revealed a greater diversity than previously reported, with 89 glycan compositions that may correspond to over 250 structures. Among th

SUBMITTER: Goonatilleke E 

PROVIDER: S-EPMC6823845 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature