GLIPR1L1 is an IZUMO-binding protein required for optimal fertilization in the mouse.

ABSTRACT:

Background

The sperm protein IZUMO1 (Izumo sperm-egg fusion 1) and its recently identified binding partner on the oolemma, IZUMO1R, are among the first ligand-receptor pairs shown to be essential for gamete recognition and adhesion. However, the IZUMO1-IZUMO1R interaction does not appear to be directly responsible for promoting the fusion of the gamete membranes, suggesting that this critical phase of the fertilization cascade requires the concerted action of alternative fusogenic machinery. It has therefore been proposed that IZUMO1 may play a secondary role in the organization and/or stabilization of higher-order heteromeric complexes in spermatozoa that are required for membrane fusion.

Results

Here, we show that fertilization-competent (acrosome reacted) mouse spermatozo

SUBMITTER: Gaikwad AS 

PROVIDER: S-EPMC6824042 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature