Effect of Combination l-Citrulline and Metformin Treatment on Motor Function in Patients With Duchenne Muscular Dystrophy: A Randomized Clinical Trial.

ABSTRACT:

Importance

Nitric oxide precursors, such as the amino acid l-arginine and the biguanide antidiabetic drug metformin, have been associated with metabolism and muscle function in patients with Duchenne muscular dystrophy (DMD). The treatment of DMD remains an unmet medical need.

Objective

To evaluate the benefits and harms of a combination of l-citrulline and metformin treatment among patients with DMD.

Design, setting, and participants

A single-center randomized double-blind placebo-controlled parallel-group clinical trial was conducted between December 12, 2013, and March 30, 2016, at the University Children's Hospital Basel in Switzerland. A total of 47 ambulant male patients aged 6.5 to 10 years with genetically confirmed DMD were recruited locally and from the pati

SUBMITTER: Hafner P 

PROVIDER: S-EPMC6824222 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature