Association Between Polygenic Risk Score and Risk of Myopia.

ABSTRACT:

Importance

Myopia is a leading cause of untreatable visual impairment and is increasing in prevalence worldwide. Interventions for slowing childhood myopia progression have shown success in randomized clinical trials; hence, there is a need to identify which children would benefit most from treatment intervention.

Objectives

To examine whether genetic information alone can identify children at risk of myopia development and whether including a child's genetic predisposition to educational attainment is associated with improved genetic prediction of the risk of myopia.

Design, setting, and participants

Meta-analysis of 3 genome-wide association studies (GWAS) including a total of 711 984 individuals. These were a published GWAS for educational attainment and 2 GWAS for

SUBMITTER: Ghorbani Mojarrad N 

PROVIDER: S-EPMC6824229 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature