Insight into the relationship between aryl-hydrocarbon receptor and β-catenin in human colon cancer cells.

ABSTRACT: β-Catenin is a multi-functional protein involved in cell adhesion and signal transduction and has a critical role in colorectal cancer development. β-Catenin positively regulates the aryl-hydrocarbon receptor (AhR) mediated signal by both induction of AhR expression and enhancement of AhR-dependent gene induction. Conversely, it was reported that AhR negatively regulates the β-catenin signal via ubiquitination and subsequent degradation in a ligand dependent manner. However, there have been conflicting data among previous studies regarding the relationship between these two proteins. In this report, we conducted confirmatory studies dissecting the relationship between AhR and β-catenin. We did not observe β-catenin degradation by AhR ligands in several colon cancer cell lines. Reporter ass

SUBMITTER: Shiizaki K 

PROVIDER: S-EPMC6824560 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature