Early signal detection of adverse events following influenza vaccination using proportional reporting ratio, Victoria, Australia.

ABSTRACT: INTRODUCTION:Timely adverse event following immunisation (AEFI) signal event detection is essential to minimise further vaccinees receiving unsafe vaccines. We explored the proportional reporting ratio (PRR) ability to detect two known signal events with influenza vaccines with the aim of providing a model for prospective routine signal detection and improving vaccine safety surveillance in Australia. METHODS:Passive AEFI surveillance reports from 2008-2017 relating to influenza vaccines were accessed from the Australian SAEFVIC (Victoria) database. Proportional reporting ratios were calculated for two vaccine-event categories; fever and allergic AEFI. Signal detection sensitivity for two known signal events were determined using weekly data; cumulative data by individual year and; cumulat

SUBMITTER: Clothier HJ 

PROVIDER: S-EPMC6824574 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature