Cobalt Catalysis for Enantioselective Cyclobutanone Construction.

ABSTRACT: Over the past 40 years, intramolecular hydroacylation has favored five-membered rings, in preference to four membered rings. Herein, we report a catalyst derived from earth-abundant cobalt that enables preparation of cyclobutanones, with excellent regio-, diastereo-, and enantiocontrol, under mild conditions (2 mol % catalyst loading and as low as 50 °C).

SUBMITTER: Kim DK 

PROVIDER: S-EPMC6824591 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature