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Nanotherapy Targeting NF-?B Attenuates Acute Pain After Joint Injury.

ABSTRACT: Inflammation after joint injury leads to joint responses that result in eventual osteoarthritis development. Blockade of inflammation, by suppressing NF-?B expression, has been shown to reduce joint injury-induced chondrocyte apoptosis and reactive synovitis in vivo. Herein, we demonstrate that the suppression of NF-?B p65 expression also significantly mitigates the acute pain sensitivity induced by mechanical injury to the joint. These results suggest that early intervention with anti-NF-?B nanotherapy mitigates both structural and pain-related outcomes, which in turn may impact the progression of post-traumatic osteoarthritis.

SUBMITTER: Yan H 

PROVIDER: S-EPMC6824724 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Nanotherapy Targeting NF-κB Attenuates Acute Pain After Joint Injury.

Yan Huimin H   Duan Xin X   Collins Kelsey H KH   Springer Luke E LE   Guilak Farshid F   Wickline Samuel A SA   Rai M Farooq MF   Pan Hua H   Pham Christine T N CTN  

Precision nanomedicine 20190112 1

Inflammation after joint injury leads to joint responses that result in eventual osteoarthritis development. Blockade of inflammation, by suppressing NF-κB expression, has been shown to reduce joint injury-induced chondrocyte apoptosis and reactive synovitis <i>in vivo</i>. Herein, we demonstrate that the suppression of NF-κB p65 expression also significantly mitigates the acute pain sensitivity induced by mechanical injury to the joint. These results suggest that early intervention with anti-NF  ...[more]

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