Biomarkers for Autism Spectrum Disorders (ASD): A Meta-analysis.

ABSTRACT: To compare the reported accuracy and sensitivity of the various modalities used to diagnose autism spectrum disorders (ASD) in efforts to help focus further biomarker research on the most promising methods for early diagnosis. The Medline scientific literature database was searched to identify publications assessing potential clinical ASD biomarkers. Reports were categorized by the modality used to assess the putative markers, including protein, genetic, metabolic, or objective imaging methods. The reported sensitivity, specificity, area under the curve, and overall agreement were summarized and analyzed to determine weighted averages for each diagnostic modality. Heterogeneity was measured using the I2 test. Of the 71 papers included in this analysis, each belonging to one of five modalit

SUBMITTER: Ansel A 

PROVIDER: S-EPMC6824829 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature