Brown Fat Promotes Muscle Growth During Regeneration.

ABSTRACT: Accumulation of adipose tissue around and within muscles is highly correlated with reduced strength, functional limitations, and poor rehabilitative outcomes. Given the intimate physical contact between these tissues, paracrine cross-talk is a likely mediator of this association. The recent discovery that muscle-associated adipose tissue exhibits features of beige fat has suggested that this cross-talk may be modifiable, as beige fat can be stimulated to assume features of brown fat. In this work, we describe a novel intermuscular fat transplant model in the mouse rotator cuff to investigate cross-talk between muscle and adipose tissue. Specifically, we examine the role of transplanted fat phenotype on muscle regeneration by transplanting pieces of classical brown (interscapular), beige (i

SUBMITTER: Bryniarski AR 

PROVIDER: S-EPMC6824921 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature