More than BOLD: Dual-spin populations create functional contrast.

ABSTRACT:

Purpose

Functional MRI contrast has generally been associated with changes in transverse relaxivity caused by blood oxygen concentration, the so-called blood oxygen level dependent contrast. However, this interpretation of fMRI contrast has been called into question by several recent experiments at high spatial resolution. Experiments were conducted to examine contrast dependencies that cannot be explained only by differences in relaxivity in a single-spin population.

Methods

Measurements of functional signal and contrast were obtained in human early visual cortex during a high-contrast visual stimulation over a large range of TEs and for several flip angles. Small voxels (1.5 mm) were used to restrict the measurements to cortical gray matter in early visual areas identified

SUBMITTER: Taylor AJ 

PROVIDER: S-EPMC6824942 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature