Genetic Selection for Alcohol Preference in Mice Alters Dorsal Striatum Neurotransmission.

ABSTRACT: BACKGROUND:Although it is widely acknowledged that the risk of developing an alcohol use disorder (AUD) is strongly influenced by genetic factors, very little is known about how this genetic predisposition may alter neurotransmission in a way that promotes AUD susceptibility. The dorsal striatum has garnered increased attention as a brain region of interest in AUD development given its significant roles in goal-directed and habitual behavior. METHODS:In the present work, dorsal striatal neurotransmission parameters were measured in preclinical mouse models of high and low AUD risk. We performed brain slice whole-cell patch clamp electrophysiological recordings from medium spiny neurons (MSNs) in the dorsomedial (DMS) and dorsolateral (DLS) striatum of naïve adult male and female selectivel

SUBMITTER: Fritz BM 

PROVIDER: S-EPMC6824951 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature