Assessment of Acute Motor Effects and Tolerance Following Self-Administration of Alcohol and Edible ∆⁹ -Tetrahydrocannabinol in Adolescent Male Mice.

ABSTRACT:

Background

Cannabinoids and their principle psychoactive target, the cannabinoid type 1 receptor (CB1R), impact a number of alcohol-related properties, and although alcohol and cannabis are often co-used, particularly in adolescence, few animal models of this phenomenon exist. We modeled the co-use of alcohol and ∆⁹ -tetrahydrocannabinol (THC) in adolescent mice using ingestive methods popular during this developmental period in humans, namely binge-drinking and edible THC. With this model, we assessed levels of use, acute effects, and tolerance to each substance.

Methods

Adolescent male C57BL/6J mice had daily, limited access to 1 of 2 edible doughs (THC or control), to 1 of 2 fluids (ethanol (EtOH) or water), and in 1 of 2 orders (dough-fluid or fluid-dough). Ho

SUBMITTER: Smoker MP 

PROVIDER: S-EPMC6824955 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature