Thyroid hormone coordinates developmental trajectories but does not underlie developmental truncation in danionins.

ABSTRACT:

Background

Differences in postembryonic developmental trajectories can profoundly alter adult phenotypes and life histories. Thyroid hormone (TH) regulates metamorphosis in many vertebrate taxa with multiphasic ecologies, and alterations to TH metabolism underlie notable cases of paedomorphosis in amphibians. We tested the requirement for TH in multiple postembryonic developmental processes in zebrafish, which has a monophasic ecology, and asked if TH production was compromised in paedomorphic Danionella.

Results

We showed that TH regulates allometric growth in juvenile zebrafish, and inhibits relative head growth. The lateral line system showed differential requirements for TH: the hormone promotes canal neuromast formation and inhibits neuromast proliferation in the head,

SUBMITTER: Hu Y 

PROVIDER: S-EPMC6824966 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature