Coronary microvascular dysfunction, left ventricular remodeling, and clinical outcomes in aortic stenosis.

ABSTRACT:

Background

We investigated role of coronary microvascular disease (CMD) in maladaptive LV remodeling and prognosis in patients with aortic sclerosis or stenosis and no overt CAD.

Methods

This was a retrospective cohort study of patients with aortic sclerosis or stenosis, normal myocardial perfusion and LV ejection fraction (EF) > 50% (n = 43) and matched controls without AS (n = 43). PET and echocardiograms were performed within 1 year of each other. Myocardial perfusion and myocardial flow reserve (MFR) were quantified using PET imaging. LV structure and function, including global longitudinal strain (GLS), were quantified by transthoracic echocardiography.

Results

Global MFR declined with increasing AS severity (P = 0.04). Probability of impaired MFR increased with

SUBMITTER: Zhou W 

PROVIDER: S-EPMC6824970 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature