Dynamic single-slice CT estimates whole-lung dual-energy CT variables in pigs with and without experimental lung injury.

ABSTRACT:

Background

Dynamic single-slice CT (dCT) is increasingly used to examine the intra-tidal, physiological variation in aeration and lung density in experimental lung injury. The ability of dCT to predict whole-lung values is unclear, especially for dual-energy CT (DECT) variables. Additionally, the effect of inspiration-related lung movement on CT variables has not yet been quantified.

Methods

Eight domestic pigs were studied under general anaesthesia, including four following saline-lavage surfactant depletion (lung injury model). DECT, dCT and whole-lung images were collected at 12 ventilatory settings. Whole-lung single energy scans images were collected during expiratory and inspiratory apnoeas at positive end-expiratory pressures from 0 to 20 cmH₂O. Means and d

SUBMITTER: Cronin JN 

PROVIDER: S-EPMC6825104 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature