Wide-area low-energy surface stimulation of large mammalian ventricular tissue.

ABSTRACT: The epicardial and endocardial surfaces of the heart are attractive targets to administer antiarrhythmic electrotherapies. Electrically stimulating wide areas of the surfaces of small mammalian ventricles is straightforward given the relatively small scale of their myocardial dimensions compared to the tissue space constant and electrical field. However, it has yet to be proven for larger mammalian hearts with tissue properties and ventricular dimensions closer to humans. Our goal was to address the feasibility and impact of wide-area electrical stimulation on the ventricular surfaces of large mammalian hearts at different stimulus strengths. This was accomplished by placing long line electrodes on the ventricular surfaces of pig hearts that span wide areas, and activating them individuall

SUBMITTER: Moreno A 

PROVIDER: S-EPMC6825186 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature