Comparison of whole blood and spleen transcriptional signatures over the course of an experimental malaria infection.

ABSTRACT: Although the spleen is broadly accepted as the major lymphoid organ involved in generating immune responses to the erythrocytic stages of the malaria parasite, Plasmodium, human splenic tissue is not readily available in most cases. As a result, most studies of malaria in humans rely on peripheral blood to assess cellular immune responses to malaria. The suitability of peripheral blood as a proxy for splenic immune responses is however unknown. Here, we have simultaneously analysed the transcriptomes of whole blood and spleen over 12 days of erythrocytic stage Plasmodium chabaudi infection in C57BL/6 mice. Using both unsupervised and directed approaches, we compared gene expression between blood and spleen over the course of infection. Taking advantage of publicly available datasets, we us

SUBMITTER: Talavera-Lopez C 

PROVIDER: S-EPMC6825210 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature