Selective Priming of Tumor Blood Vessels by Radiation Therapy Enhances Nanodrug Delivery.

ABSTRACT: Effective drug delivery is restricted by pathophysiological barriers in solid tumors. In human pancreatic adenocarcinoma, poorly-permeable blood vessels limit the intratumoral permeation and penetration of chemo or nanotherapeutic drugs. New and clinically viable strategies are urgently sought to breach the neoplastic barriers that prevent effective drug delivery. Here, we present an original idea to boost drug delivery by selectively knocking down the tumor vascular barrier in a human pancreatic cancer model. Clinical radiation activates the tumor endothelial-targeted gold nanoparticles to induce a physical vascular damage due to the high photoelectric interactions. Active modulation of these tumor neovessels lead to distinct changes in tumor vascular permeability. Noninvasive MRI and flu

SUBMITTER: Kunjachan S 

PROVIDER: S-EPMC6825216 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature