Ontology highlight
ABSTRACT:
SUBMITTER: Halfon Y
PROVIDER: S-EPMC6825255 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20191014 44
Resistance to antibiotics has become a major threat to modern medicine. The ribosome plays a fundamental role in cell vitality by the translation of the genetic code into proteins; hence, it is a major target for clinically useful antibiotics. We report here the cryo-electron microscopy structures of the ribosome of a pathogenic aminoglycoside (AG)-resistant <i>Pseudomonas aeruginosa</i> strain, as well as of a nonresistance strain isolated from a cystic fibrosis patient. The structural studies ...[more]