Gastrointestinal dysfunction in autism displayed by altered motility and achalasia in Foxp1^+/- mice.

ABSTRACT: Gastrointestinal dysfunctions in individuals with autism spectrum disorder are poorly understood, although they are common among this group of patients. FOXP1 haploinsufficiency is characterized by autistic behavior, language impairment, and intellectual disability, but feeding difficulties and gastrointestinal problems have also been reported. Whether these are primary impairments, the result of altered eating behavior, or side effects of psychotropic medication remains unclear. To address this question, we investigated Foxp1^+/- mice reflecting FOXP1 haploinsufficiency. These animals show decreased body weight and altered feeding behavior with reduced food and water intake. A pronounced muscular atrophy was detected in the esophagus and colon, caused by red

SUBMITTER: Frohlich H 

PROVIDER: S-EPMC6825283 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature