Perfusion and apparent oxygenation in the human placenta (PERFOX).

ABSTRACT:

Purpose

To study placental function-both perfusion and an oxygenation surrogate ( T2* )-simultaneously and quantitatively in-vivo.

Methods

Fifteen pregnant women were scanned on a 3T MR scanner. For perfusion measurements, a velocity selective arterial spin labeling preparation module was placed before a multi-echo gradient echo EPI readout to integrate T2* and perfusion measurements in 1 joint perfusion-oxygenation (PERFOX) acquisition. Joint motion correction and quantification were performed to evaluate changes in T2* and perfusion over GA.

Results

The optimized integrated PERFOX protocol and post-processing allowed successful visualization and quantification of perfusion and T2* in all subjects. Areas of high T2* and high perfusion appear to correspond to placenta

SUBMITTER: Hutter J 

PROVIDER: S-EPMC6825519 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature