Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation.

ABSTRACT:

Purpose

Despite the accumulation of extensive genomic alterations, many cancers fail to be recognized as "foreign" and escape destruction by the host immune system. Immunotherapies designed to address this problem by directly stimulating immune effector cells have led to some remarkable clinical outcomes, but unfortunately, most cancers fail to respond, prompting the need to identify additional immunomodulatory treatment options.Experimental Design: We elucidated the effect of a novel treatment paradigm using sustained, low-dose HSP90 inhibition in vitro and in syngeneic mouse models using genetic and pharmacologic tools. Profiling of treatment-associated tumor cell antigens was performed using immunoprecipitation followed by peptide mass spectrometry.

Results

SUBMITTER: Jaeger AM 

PROVIDER: S-EPMC6825536 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature