Relationship between Diabetes and Diabetes Medications and Risk of Different Molecular Subtypes of Breast Cancer.

ABSTRACT:

Background

Type II diabetes and certain diabetes treatments have been observed to impact breast cancer risk. However, their associations with different breast cancer molecular subtype defined by estrogen receptor (ER)/progesterone receptor (PR)/HER2 status are unclear.

Methods

We conducted a retrospective multi-center population-based case-case study consisting of 4,557 breast cancer cases to evaluate the impact of type II diabetes and diabetes medications on the risk of different breast cancer molecular subtypes [ER⁺/HER2^-, ER⁺/HER2⁺, triple negative (ER^-/PR^-/HER2^-), and HER2 overexpressing (H2E, ER^-/PR^-/HER2⁺)]. Using ER⁺/HER2^- cases as the re

SUBMITTER: Chen H 

PROVIDER: S-EPMC6825551 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature