Evidence for Etiologic Subtypes of Breast Cancer in the Carolina Breast Cancer Study.

ABSTRACT:

Background

Distinctions in the etiology of triple-negative versus luminal breast cancer have become well established using immunohistochemical surrogates [notably estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2)]. However, it is unclear whether established immunohistochemical subtypes are the sole or definitive means of etiologically subdividing breast cancers.

Methods

We evaluated clinical biomarkers and tumor suppressor p53 with risk factor data from cases and controls in the Carolina Breast Cancer Study, a population-based study of incident breast cancers. For each individual marker and combinations of markers, we calculated an aggregate measure to distinguish the etiologic heterogeneity of different classification sc

SUBMITTER: Benefield HC 

PROVIDER: S-EPMC6825567 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature